Makes an attempt to find a breakthrough dementia drug is perhaps drawing consideration as of late, however conventional medicinal merchandise can provide hints for preventive drugs.
A analysis group led by Specifically Appointed Professor Takami Tomiyama of Osaka Metropolitan College’s Graduate Faculty of Drugs has discovered that administering the dried seeds of a sort of jujube referred to as Ziziphus jujuba Miller var. spinosa, used as a medicinal herb in conventional Chinese language drugs, holds promise in restoring cognitive and motor operate in mannequin mice.
By administering sizzling water extracts of Zizyphi spinosi semen to mannequin mice with Alzheimer’s illness, frontotemporal dementia, Parkinson’s illness, and dementia with Lewy our bodies, the group discovered that cognitive and motor features have been restored.
Moreover, when the seeds have been merely crushed into powder and administered to the mannequin mice, the group found that the cognitive operate of the mannequin mice recovered to a degree above that of management mice. As well as, the powders apparently suppressed mobile ageing in older mice and improved their cognitive operate to an identical degree as youthful mice.
Beforehand, members of the analysis group reported individually that the pathology of dementia in mannequin mice improved with cognitive and motor features restored after utilizing the Hawaiian herb mamaki and the Chinese language herb Acorus gramineus.
The outcomes of our analysis will hopefully make it doable to develop dementia prevention merchandise that middle-aged and aged folks can take at their very own discretion.”
Takami Tomiyama, Professor, Graduate Faculty of Drugs, Osaka Metropolitan College
The findings are at the moment obtainable as a reviewed preprint in eLife.
Supply:
Journal reference:
Umeda, T., et al. (2024) Merely crushed Zizyphi spinosi semen prevents neurodegenerative ailments and reverses age-related cognitive decline in mice. doi.org/10.7554/elife.100737.1.
