Ben’s Peptide Stack for Restoration, Explosive Positive factors, & Ageless Vitality

September 17, 2024

Peptides—quick chains of amino acids which are the “constructing blocks” of proteins—will be extraordinarily efficient for focusing on a single pathway or mechanism within the physique with nice precision. For instance, BPC-157 will help you get well sooner by quelling irritation, LL-37 can assist a greater immune system and squash a bout of SIBO, giardia, or different intestine points, and Semax will be efficient as a potent nootropic or good drug equal for cognitive efficiency.

While you “stack” a number of peptides, nevertheless, and use them collectively in a multi-targeted method for a broader well being objective, their advantages can compound and change into much more highly effective—typically serving to you expertise important enchancment in a a lot shorter time frame.

However in terms of which peptides work collectively, these you may stack collectively safely and successfully, what doses to make use of, and the way typically to take every—issues can get a bit complicated, to say the very least.

So on this article, I’m going to interrupt down the perfect peptide stacks (together with a number of that I’ve used efficiently myself) to focus on restoration, muscle acquire, fats loss, immunity, anti-aging, and extra.

I’ll additionally cowl advisable tips for dosing every peptide, the frequency they need to be administered, whether or not peptides ought to be cycled on and off through the yr, the perfect time of day to take peptides, and way more!

Disclaimer: I’m not a physician and this isn’t to be taken, interpreted, or construed as medical recommendation. These are simply my private ideas and never a prescription, a analysis, or any type of well being care by any means. Please speak with a licensed medical skilled if you happen to’re desirous about utilizing peptides. As of now, peptide remedy is taken into account “experimental” and lacks scientific long-term analysis, so you need to proceed at your individual threat. As well as, most of these things is banned by the World Anti-Doping Affiliation (WADA), US Anti-Doping Affiliation (USADA), and different worldwide governing our bodies of sport, so you shouldn’t use any of those compounds in case you are competing in any sanctioned sport. Additionally, please notice that the world of peptides is ever-evolving, and whereas I do attempt to hold posted articles up to date, I can solely attest that this info is present as of September 2024. To verify in case your peptide is authorized, go to globaldro.com, choose your nation, and have the identify of the medicine readily available to see if it is banned in any athletic sport. 

The Finest Peptide Stacks for Your Well being Objectives

Now, earlier than I bounce headfirst into the peptide stacking deep finish, let me give only one extra fast disclaimer (isn’t this authorized stuff enjoyable?!)…

…the dosing and frequency suggestions offered under are merely common tips.

Like several medicine or complement, peptide doses will change based mostly in your physique weight, dimension, and private well being standing. I like to recommend you begin on the decrease finish of a peptide dose and frequency to see the way you personally reply. Above all, you need to comply with the directions out of your doctor or peptide producer.

I might additionally extremely suggest that you just assessment the detailed directions for reconstitution, storage, and administration offered on this article earlier than continuing.

The “Get well Like Wolverine” Peptide Stack

Considered one of my first critical forays into peptides was to heal an annoying, persistent, and fairly painful torn higher hamstring by utilizing what I name the “Get well Like Wolverine” stack.

And it labored—with fairly stunning pace, no much less.

So you probably have irritating joint ache that will not go away, some type of muscle tear or sprain, or just wish to improve your athletic restoration, this peptide stack beats the pants off your typical old-school “R.I.C.E.” protocol (relaxation, ice, compression, and elevation).

This potent restoration stack incorporates the next peptides: BPC-157, TB-500, ipamorelin, tesamorelin, and GHK-Cu.

BPC-157

Remoted from a bigger peptide referred to as “physique defending compound,” which is of course present in human gastric juice, BPC-157 has quite a few advantages. These embrace regenerative results resembling therapeutic muscle tissues, tendons, ligaments, bones, and pores and skin burns, in addition to rising blood movement by way of angiogenesis and providing highly effective anti-inflammatory properties. It will also be taken orally—firms resembling CanLab, Peptide Sciences, Limitless Life, and LVLUP Well being have entry to oral variations of BPC-157 and several other of the opposite peptides listed under. 

The directions under embrace tips if you happen to’re taking oral tablets.

• Dosing Pointers:
  • Injection: 250–350mcg 2x/day; OR
  • Injection: 500–700 mcg 1x/day; OR
  • Injection: 0.15mL of 2000mcg/mL answer day-after-day for a 30-day cycle; OR
  • Oral: 500mcg capsules for a 30-day cycle
• Administration Route:
  • Subcutaneous injection for systemic therapeutic
  • Intramuscular injection for focused therapeutic
  • Orally for intestine therapeutic or comfort

Once more, you may click on right here for dosing/reconstituting directions. Sadly, as of January 1, 2022, the World Anti-Doping Company listed BPC-157 as a prohibited substance, that means athletes topic to WADA rules are not allowed to make use of it in competitors or coaching, because it may lead to disqualification or penalties.

TB-500 (Thymosin Beta-4)

TB-500 is a naturally produced peptide present in almost each a part of the human physique. It will increase the exercise of the muscle protein actin to advertise mobile progress and stimulate blood cell improvement and has been proven to restore harm to the center, pores and skin, tissue, ligaments, and different organs and supply ache aid. It’s most likely the perfect peptide for muscle restore, nevertheless, TB-500 is banned by WADA and most different world sporting organizations each in-competition and out-of-competition.

But, if you happen to’re trying to promote wound restore and therapeutic, it’s an unbelievable answer as a result of it acts on actin and myosin fibers in tendons, ligaments, and muscle tissues—which can also be doubtless why this peptide is used as a preferred therapeutic and restoration technique within the horse-racing trade.

• Dosing Pointers: Please notice that there are only a few tips round dosing TB-500, so it’s greatest to comply with your practitioner or producer’s solutions. Nevertheless, here’s what I’ve used:
  • 5-2.5 mg, 2–3x/week; OR
  • 25mL of 3000mcg/mL answer each day for a 20-day cycle
• Administration Route:
  • Subcutaneous or intramuscular injection

Ipamorelin

Ipamorelin enhances restoration by way of the activation of human progress hormone (referred to as a “progress hormone secretagogue”), which is well-known to speed up the therapeutic course of. Not like utilizing human progress hormone (HGH) instantly, nevertheless, ipamorelin—when used at acceptable doses—seems to be comparatively freed from uncomfortable side effects and won’t have an effect on or intrude along with your physique’s pure manufacturing of GH.

• Dosing Pointers:
  • 100-500mcg 1-3x/day; OR
  • 10mL of 2000mcg/mL answer 1x/day, 5 days per week
• Administration Route:
• Timing Suggestions:
  • For greatest outcomes, it’s endorsed to manage ipamorelin on the similar time each day and keep away from consuming meals and enormous quantities of liquids not less than 1 hour earlier than and after.

Tesamorelin

Tesamorelin is like ipamorelin’s cousin; it promotes restoration by way of the identical GH pathways, serving as a “progress hormone stimulating hormone.” In different phrases, it binds to and stimulates progress hormone receptors with related efficiency as taking endogenous HGH—once more, with out the undesirable uncomfortable side effects.

• Dosing Pointers:
  • 1mg 1–2x/day for five days per week for a 6–8 week cycle; OR
  • 5mL of 1mg/0.6mL answer 1x/day, 6 days per week for a 6–8 week cycle
• Administration Route:
• Timing Suggestions:
  • Earlier than mattress, take it not less than 90 minutes after consuming. Upon waking, take tesamorelin ideally earlier than train and consuming.

GHK-Cu

GHK-Cu is a naturally occurring copper advanced present in human plasma, saliva, and urine. It has many roles within the physique, together with selling restoration. It appears to behave as an anti-inflammatory agent that controls oxidative harm post-tissue harm, in addition to signaling tissue transforming and the technology of latest, wholesome tissue. Whereas GHK-Cu is greatest injected subcutaneously for restoration, it will also be used topically/transdermally for different functions like pores and skin well being or hair regrowth—such because the case with Jay Campbell’s hair regrowth peptide system.

• Dosing Pointers:
  • 5mg 1x/day for a 5–10 day cycle; OR
  • 2mL of 10mg/mL answer 2x/day
• Administration Route:

Here’s a record of assets to find much more about these particular peptides:

• How To Use BPC-157: A Full Dummies Information To Therapeutic The Physique Like Wolverine.
• How To Construct New Blood Vessels, Regenerate Muscle Tissue Fibers, Enhance New Cell Progress & Extra With One thing Known as “TB-500.”
• Demystifying Progress Hormone-Releasing Peptides – Every little thing You Want To Know About GH, Ipamorelin, Tesamorelin & Extra!
• The Coolest, Craziest Peptides You’ve By no means Heard Of (& The place To Get Them), Boosting Testosterone With out Medicine, The Latest Creatine Booster & Extra With LVLUP Well being’s Kyal Van Der Leest
• How To Use Testosterone, Peptide Stacks That Will Blow Your Thoughts, The Fact About Getting Peptides On The Web, & A lot Extra With Jay Campbell.

The “Lean and Imply” Peptide Stack (Muscle Acquire & Fats Loss)

As I’ve said many, many occasions all through my profession, muscle mass is just not solely useful for staying robust and searching good bare ;), it’s additionally important to sustaining an extended and wholesome life.

So, if you happen to’re desirous about getting larger, stronger, sexier, and sooner with age—along with lifting heavy issues, consuming sufficient protein, and avoiding inflammatory meals—peptides will be one other software in your toolkit that will help you concurrently construct muscle and burn fats.

(P.S.: This stack would work wonders when mixed with the train, way of life, and biohacking ideas lined in my article “Horny Endlessly: How To Construct Useful, Good-Trying Muscle For Life”). I notably like this one for morning fasted exercises.

This muscle acquire/fats loss stack contains the next peptides: IGF-1 LR3, ipamorelin, CJC-1295 (with out DAC), and tesamorelin.

IGF-1 LR3

There are principally two mechanisms by which you’ll be able to enhance muscle mass: hypertrophy (enhance in muscle fiber dimension) or hyperplasia (enhance in muscle fiber quantity).

IGF-1 LR3, which is basically the long-acting model of IGF-1, a potent anabolic peptide, works to extend muscle by stimulating hyperplasia.

• Dosing Pointers:
  • 50–150mcg 1x/day for a 4-week cycle; OR
  • 4mL of 620mcg/mL answer 1x/day
• Administration Route:

Ipamorelin

As a result of it will increase progress hormone (GH) secretion, Ipamorelin can also be a potent muscle-building peptide. GH has main results on skeletal muscle and performance, which is why it’s such a extensively used (and abused) sports activities efficiency drug.

• Dosing Pointers:
  • 100–500mcg 1–3x/day for a 12-week cycle; OR
  • 10mL of 2000mcg/mL answer 1x/day, 5 days per week
• Administration Route:
• Timing Suggestions:
  • For muscle acquire/fats loss, I’ve personally seen the perfect outcomes utilizing ipamorelin earlier than bedtime on an empty abdomen.

CJC-1295 with out DAC (Modified GRF 1-29)

CJC-1295 features as a progress hormone-releasing hormone (GHRH) and will increase IGF-1, which helps promote fats loss and elevated muscle protein synthesis.

For this stack, you’ll wish to use CJC with out DAC (drug affinity advanced), which is the shorter-acting model that extra carefully mimics your physique’s pure progress hormone pulses.

• Dosing Pointers:
  • 100mcg 1–3x/day for a 12-week cycle; OR
  • 10mL of 2000mcg/ml answer 1x/day, 5 nights per week
• Administration Route:
• Timing Suggestions:
  • Take CJC-1295 earlier than bedtime on an empty abdomen.

Tesamorelin

Tesamorelin’s mechanism of motion is similar to that of ipamorelin; it really works on progress hormone pathways and stimulates IGF-1, which triggers the manufacturing of muscle protein. It’s additionally been proven in massive scientific trials to lower visceral fats and cut back ranges of triglyceride within the blood.

• Dosing Pointers:
  • 1mg 1–2x/day for five days per week; OR
  • 5mL of 1mg/0.6mL answer 1x/day, 6 days per week
• Administration Route:
• Timing Suggestions:
  • For muscle acquire/fats loss, I’ve skilled the perfect outcomes by taking tesamorelin within the morning earlier than my fasted exercise. However you can even take it earlier than mattress, not less than 90 minutes after consuming.

Sources to be taught extra about these particular peptides:

The “By no means Get Sick” Immunity Peptide Stack

You might be, like me, pulling out all of the stops to bolster your immune techniques today.

Peptides will be extremely efficient for focusing on the multi-faceted immune system—which incorporates many organs, cells, and signaling molecules—offering you with well-rounded assist to fight no matter comes your manner.

(P.S.: This stack could be glorious for supporting your immune system when mixed with the opposite solutions in my article, “Three Little Identified, Unconventional Antiviral Approaches For Boosting Your Immune System.”)

This immune-boosting stack contains the next peptides: TB-500, thymalin, and LL-37.

TB-500 (Thymosin Beta-4)

You don’t hear about it a lot, however the humble thymus gland is essential in creating your immune system. Thymosin beta-4, a peptide produced by this gland, performs a big function in regulating immunity and producing white blood cells, lymphocytes, T cells, B cells, and antibodies.

• Dosing Pointers: There are only a few tips round dosing TB-500, so it’s greatest to comply with your practitioner or producer’s solutions. Nevertheless, here’s what I’ve used:
  • 750mcg 1x/day, cycle for 3 months on/3 months off; OR
  • 3mg each different day, cycle for 3 months on/3 months off; OR
  • 25mL of 3000mcg/mL answer each day for a 20-day cycle
• Administration Route:

Thymalin

Thymalin is yet one more immune-boosting peptide produced by the thymus gland. It has immunomodulatory properties and performs a job in Th1 cytokine manufacturing (proinflammatory) and T cell (cell-mediated immunity) manufacturing and performance, each of that are important for antiviral protection.

• Dosing Pointers:
  • 5–10mg 1x/day for 3-10 days, repeat each 6–12 months
• Administration Route:
  • Subcutaneous or intramuscular injection

LL-37

Analysis on this so-called “antimicrobial peptide” signifies that it additionally has antibiotic, antifungal, and antiviral properties. Thus, it could be extremely efficient for autoimmune points and intestine situations, together with fungal and bacterial overgrowth.

Warning: If in case you have SIBO, the die-off and Jarisch-Herxheimer Response from LL-37 will be uncomfortable and will contain flu-like signs and diarrhea for as much as two weeks. After that, nevertheless, many individuals expertise the whole decision of SIBO signs and the elimination of bloating and gasoline in response to carbohydrate consumption.

• Dosing Pointers:
  • 100mcg 2x/day for 4–6 weeks
• Administration Route:

Sources to be taught extra about these particular peptides:

The “Benjamin Button” Anti-Growing old & Longevity Peptide Stack

Considered one of my private favourite methods to stack peptides is to “sluggish the getting old course of” and promote longevity—principally turning me right into a real-life Benjamin Button.

All joking apart, there’s critically compelling analysis related to peptides and getting old. One concept, postulated by Professor Vladimir Khavinson, who is maybe probably the most distinguished medical gerontology researcher in Russia, is that most of the woes of getting old are as a result of slow-bleed, steady breakdown of proteins (bear in mind: proteins are manufactured from peptide chains) in tissues and organs, which results in their eventual degradation and full-body getting old.

Nevertheless, if you replenish your peptide shops, they’re capable of restimulate protein synthesis in tissues. Which means that as an alternative of experiencing protein degradation and organ breakdown with age, peptides allow you to truly restore as you become older. Fairly cool, proper?

This anti-aging stack contains the next peptides: epithalon, thymalin, GHK-Cu, MOTS-C, humanin, and FOXO4-DRI.

Epithalon

Epithalon (additionally confusingly known as epitalon, no “h”) is usually known as the “main anti-aging peptide” as a result of it is likely one of the only a few synthesized compounds that has been proven to instantly activate the telomerase enzyme in people. Telomerase renews and elongates telomeres, the caps on the ends of chromosomes that shield DNA from harm and cancer-causing errors. By activating telomerase, epithalon can cut back the shortening of telomeres, theoretically serving to you “age backward.”

I personally use the “Khavinson Protocol” for dosing epithalon (sure, the exact same aforementioned professor), which makes use of the precise dosage from a fifteen-year longevity examine in people that produced spectacular outcomes for controlling telomere shortening.

• Dosing Pointers:
  • Khavinson Protocol: 5–10mg 3x/week for 3 weeks, cycle 1x/yr; OR
  • 1mL of 3000mcg/mL answer, 1x/day
• Administration Route:
• Timing Suggestions:
  • Epithalon is greatest administered within the morning.

Thymalin

Thymalin is a peptide produced by the thymus and pineal gland. It has a constructive impact on nearly each system within the physique, together with the immune, cardiovascular, endocrine, and nervous techniques.

This peptide can also be believed to have the ability to delay human life, which is why it’s an necessary a part of this longevity stack. A 2003 examine discovered that 2–3 years of remedy with thymalin was proven to scale back all-cause mortality for aged volunteers by an element of two!

• Dosing Pointers:
  • 5–10mg 1x/day for 10 days, cycle 1–2x/yr
• Administration Route:
  • Subcutaneous or intramuscular injection

GHK-Cu

GHK-Cu helps to maintain you younger and supple in quite a few methods, together with selling wound therapeutic and tissue regeneration (pores and skin, hair follicles, abdomen, bone tissue), rising collagen and glycosaminoglycans, selling blood vessel progress, possessing antioxidant and anti inflammatory results, and way more.

This peptide can be utilized topically/transdermally—resembling in skincare or hair regrowth formulation—or injected for systemic results.

• Dosing Pointers:
  • Injection: 0.2mL of 100mg/mL, 1x/day
  • Transdermal: 1mL utilized 1x/day at evening
• Administration Route:
  • Subcutaneous injection for systemic results
  • Transdermal software for topical results (hair, pores and skin)

MOTS-c

Anti-aging researchers are actually conscious of the potent function metabolic well being and mitochondria play in longevity. MOTS-c is one peptide that powerfully impacts each of those elements, serving as a potent metabolic regulator that may improve autophagy, restore mitochondrial perform, and enhance insulin sensitivity.

It’s additionally been known as “train in a bottle” as a result of it will possibly mimic a number of the results of train by activating the AMP-Okay pathway.

• Dosing Pointers:
  • 10mg 1x/week for 10 weeks, 1x/yr
• Administration Route:
• Timing Suggestions:
  • For added mitochondrial profit, administer MOTS-c proper earlier than endurance train, ideally within the morning.

Humanin

Humanin is one other mitochondrial peptide and has been proven to produce robust cytoprotective actions in opposition to a wide range of stressors and age-related ailments, together with neurological issues, mitochondrial dysfunction, oxidative stress, hypoxic harm to the mind, and oxidized LDL ldl cholesterol.

Curiously, kids of centenarians (people that reside to be over 100 years previous) have unusually excessive ranges of humanin—a possible Fountain of Youth, maybe?

• Dosing Pointers: There are only a few tips round dosing humanin so it’s greatest to comply with your practitioner or producer’s solutions. Nevertheless, right here is the vary I’ve seen advisable (I might not counsel exceeding 0.04mg/kg physique weight per day).
  • 1–1.0mg 1–2x/day for a 2–8 week cycle, 1x/yr
• Administration Route:

FOXO4-DRI

FOXO4-DRI (D-retro inversion isoform) is a cell-penetrating peptide that’s been proven in mice to selectively trigger destruction, or induce apoptosis, of senescent cells. Senescent cells cease multiplying however they don’t die off when they need to, which might result in extra irritation and accelerated getting old. Actually, mobile senescence has been tied to quite a few age-related situations like most cancers, diabetes, osteoporosis, Alzheimer’s, and dementia. So by selectively focusing on these senescent cells, FOXO4 will help cut back the danger of ailments associated to getting old. Fairly cool!

• Dosing Pointers:
  • 3mg each different day for six days, repeat 1–3x/yr
• Administration Route:

Sources to be taught extra about these particular peptides:

Abstract

So, there you could have it.

You are formally geared up with a number of the most potent peptide stacks on the market for recovering sooner, constructing muscle and shedding fats, having a rock-solid immune system, and residing an extended, wholesome life.

To be sincere, I want I had this information once I was first tinkering with peptides a couple of years in the past—it certain would have saved me a complete heck of numerous time, cash, and self-experimentation. Hopefully, you discover it as useful as I might have again then!

In case you’re desirous about any of the peptides talked about above (from trusted, respected sources) you can even try my Peptides Sources Web page.

In abstract…

To “get well like Wolverine,” you may stack:

If you wish to lose fats and acquire muscle, mix these peptides:

For enhancing your immune system, attempt stacking:

Lastly, to age gracefully and with an excellent healthspan and lifespan, use this final anti-aging peptide stack:

Keep in mind: In case you want info on sourcing, administration, reconstitution, or different ideas for getting began, make sure to try this text, as nicely.

Moreover, if you wish to take your well being optimization to the following stage, think about diving deeper into the methods and insights shared above in my model new, not too long ago up to date, best-selling e-book, Boundless (you may pre-order your copy now!). In Boundless, you will discover complete steerage on enhancing mitochondrial perform, optimizing circadian rhythms, and enhancing sleep, amongst different superior strategies for reinforcing your well being and longevity. Whether or not you are desirous about good medicine, peptides, or cutting-edge wellness practices, this e-book covers all of it, offering actionable methods to raise your bodily and psychological well-being.

And, as all the time, I would love to listen to your ideas, questions, and suggestions, so be at liberty to drop me a line within the feedback part under, and I am going to make sure to reply!