FOCUSED-AF: Your Secret Weapon To Higher Mind Perform

When you’re in search of a strategy to increase your cognitive perform and enhance your focus and reminiscence, look no additional than FOCUSED-AF.

FOCUSED-AF combines the distinctive traits of a number of high-grade nootropics, making a synergistic impact to assist optimize your cognitive skills and aid you carry out at your greatest.

Here is what you are going to get in

FOCUSED-AF

Vitamin B6 (as Pyridoxine HCI) 

Vitamin B6, also referred to as pyridoxine, is a water-soluble vitamin that your physique wants for a number of features.  It’s important to protein, fats and carbohydrate metabolism and the creation of pink blood cells and neurotransmitters.  Your physique can not produce vitamin B6, so it’s essential to acquire it from meals or dietary supplements.  Consuming satisfactory quantities of vitamin B6 is vital for optimum well being and should even forestall and deal with continual ailments.  

Listed here are 9 well being advantages of vitamin B6, backed by science:

1. Might enhance temper and cut back signs of despair
2. Might promote mind well being and cut back Alzheimer’s threat
3. Might forestall and deal with anemia by aiding hemoglobin manufacturing
4. Could also be helpful in treating signs of PMS
5. Might assist deal with nausea throughout being pregnant
6. Might forestall clogged arteries and cut back coronary heart illness threat
7. Might assist forestall most cancers
8. Might promote eye well being and forestall eye ailments
9. Might deal with irritation related to Rheumatoid arthritis

(Nationwide Institutes of Well being: Workplace of Dietary Dietary supplements)

Vitamin B12 (as Methylcobalamin) 

Vitamin B12, also referred to as cobalamin, is an important vitamin that your physique wants however can not produce.  It’s discovered naturally in animal merchandise, but additionally added to sure meals and out there as an oral complement or injection.  Vitamin B12 has many roles in your physique. It helps the traditional perform of your nerve cells and is required for pink blood cell formation and DNA synthesis.  Vitamin B12 might profit your physique in spectacular methods, reminiscent of by boosting your power, enhancing your reminiscence and serving to forestall coronary heart illness.

Listed here are 9 well being advantages of vitamin B12, all primarily based on science.

1. Helps With Pink Blood Cell Formation and Anemia Prevention
2. Might Forestall Main Delivery Defects
3. Might Assist Bone Well being and Forestall Osteoporosis
4. Might Scale back Your Danger of Macular Degeneration
5. Might Enhance Temper and Signs of Melancholy
6. Might Profit Your Mind by Stopping the Lack of Neurons
7. Might Give You an Power Increase
8. Might Enhance Coronary heart Well being by Lowering Homocysteine
9. Helps Wholesome Hair, Pores and skin and Nails

(Meals Nutr Bull. 2008 Jun;29(2 Suppl):S101-11; dialogue S112-5)

Alpha GPC 50% (L-Alpha-glyceryl phosphorylcholine)

A pure choline compound discovered within the mind and some of the bioavailable types of choline. It’s identified to reinforce a chemical within the mind referred to as acetylcholine which is essential for reminiscence and studying features. Alpha GPC can assist cognitive well being, enhance reminiscence, and studying, and it additionally acts as a neuroprotective agent. The principle mechanism of motion is by growing acetylcholine and dopamine within the mind which is thought to considerably improve mind perform. (Clin Ther. 2003 Jan;25(1):178-93)

Bacopa (Bacopa monnieri)(complete plant)(std for 20% bacosides)

Bacopa monnieri has been utilized by Ayurvedic medical practitioners for hundreds of years for a wide range of functions, together with enhancing reminiscence and decreasing nervousness. Analysis signifies it could increase mind perform and alleviate nervousness and stress, amongst different advantages. A category of highly effective compounds referred to as bacosides in Bacopa monnieri is believed to be answerable for these advantages.  

Beneath are seven rising advantages of Bacopa monnieri:

1. Incorporates highly effective antioxidants
2. Might cut back irritation
3. Might increase mind perform
4. Might assist cut back ADHD signs
5. Might forestall nervousness and stress
6. Might assist decrease blood stress ranges
7. Might have anticancer properties

(J Altern Complement Med. 2008 Jul; 14(6): 707–713)

Lutemax 2020 (Lutein & Zeaxanthin)

Out of greater than 600 carotenoids present in nature, the three macular carotenoids—lutein, RR-zeaxanthin, and RS (meso)-zeaxanthin—have garnered appreciable consideration for his or her position in preserving wholesome imaginative and prescient. There’s a rising settlement that macular carotenoids are conditionally important vitamins, which is to say that underneath sure circumstances, supplementation could also be required. Poor dietary consumption elevated blue gentle publicity, and present way of life adjustments are driving a better have to complement with these vital vitamins to make sure satisfactory ranges all through life.

Along with the well being advantages to imaginative and prescient, the macular carotenoids inside Lutemax 2020 are helpful for:

• Higher bioavailability – Lutemax 2020 quickly elevated serum ranges of lutein and zeaxanthin in affiliation with elevated macular pigment optical density (MPOD) in as little as 8-weeks.
• Improved visible efficiency – Lutemax 2020 persistently improved distinction sensitivity, photo-stress restoration, and incapacity glare thresholds
• The B.L.U.E. research – This research was the primary human scientific trial in younger, wholesome topics and there have been enhancements in outcomes related to extended blue gentle publicity from digital gadgets, together with eye pressure and fatigue, headache frequency, and glare tolerance.
• Stress and temper assist – Lutemax 2020 considerably decreased stress, serum cortisol, and signs of suboptimal emotional and bodily well being and highlighted the significance of macular carotenoids for day by day stress assist.
• Cognitive assist – Lutemax 2020 elevated brain-derived neurotrophic issue (BDNF), which is a key molecule concerned in plastic adjustments associated to studying and reminiscence. It improved a number of parameters of cognitive efficiency, together with composite reminiscence, verbal reminiscence, sustained consideration, psychomotor velocity, and processing velocity.
• Sleep high quality – Blue gentle performs a job in regulating sleep/wake cycles, and Lutemax 2020 considerably improves sleep high quality in topics uncovered to extend blue gentle from sources reminiscent of digital gadgets.
• Pores and skin well being – Photoaging is answerable for 90 % of seen adjustments to the pores and skin and carotenoids like lutein can assist assist a more healthy, younger-looking look.
• Security – The security of Lutemax 2020 was been established by in vitro, animal, and human research. These research have been the premise of Lutemax 2020’s US FDA-notified GRAS affirmation.

 Fig: Change in scores at 6 months in placebo vs. mixed complement teams (MXan), for 5 parameters of cognitive efficiency. Knowledge factors are means +/− commonplace deviations. Asterisks point out statistical significance ( p < .05).

(N.T. Stringham, P.V. Holmes, J.M. Stringham, Physiol. Behav. 211 (2019).)

Pure Caffeine (from Inexperienced Tea)

Pure caffeine is the kind of caffeine that’s naturally present in meals like espresso, tea, and chocolate. It really works by blocking adenosine receptors in your mind.

Adenosine is a neurotransmitter that relaxes your mind, making you are feeling drained. By blocking adenosine receptors, caffeine prevents adenosine from binding to them. This retains your mind from realizing that it’s drained, which is why caffeine is so efficient at preventing off sleepiness and serving to you stay extra alert.

Despite the fact that pure and artificial caffeine have the identical bodily results, listed below are a pair advantages of pure caffeine:

• Meals With Pure Caffeine Are Extra Nutrient-Wealthy – Meals with pure caffeine are nutrient-rich. Pure caffeine incorporates antioxidants and vitamins like manganese, potassium, magnesium, and several other sorts of B nutritional vitamins.
• Pure Caffeine Might Have Fewer Dangerous Compounds – Pure caffeine doesn’t include dangerous chemical compounds like ammonia, urea, or chloroform. And pure caffeine doesn’t have a blueish glow.

(Justin Evans, John R. Richards, Amanda S. Battisti; Caffeine  StatPearls)

Mucuna Pruriens Extract (std to 98%) 

Mucuna is a tropical legume that’s very wealthy in L-Dopa—L-Dopa is the precursor to dopamine, norepinephrine, and epinephrine. It could possibly promote wholesome neurotransmission perform and improve your temper and immune system.  The mechanism of motion for mucuna is by growing dopamine within the mind. This mind chemical (or neurotransmitter) is answerable for modulating a number of cognitive features together with temper, hand-eye-coordination, and others.

Mucuna could be a highly effective software to enhance reminiscence and cognitive skills.  Analysis signifies that L-DOPA was in a position to forestall the lower in testosterone ranges which is regarded as on account of dopamine’s skill to inhibit prolactin (a hormone answerable for decreasing the degrees of luteinizing hormone and testosterone). As well as, mucuna was proven to extend testosterone ranges in infertile males from ages 25 to 40. (J Younger Pharm. 2011 Apr;3(2):119-24)

Huperzine A 1% (Huperzia serrata Leaf Extract)

Huperzine-A is an alkaloid extracted from membership moss (Huperzia Serrata) that has demonstrated each reminiscence enhancement and neuroprotective results in animal and scientific trials.

Its mechanisms of motion are:

Inhibits an enzyme that breaks down acetylcholine: Huperzine-A is a potent, reversible, and particular inhibitor of the enzyme acetylcholinesterase (ACHE), which breaks down acetylcholine. As well as, huperzine A additionally has different brain-supporting results that don’t contain ACH.

Will increase acetylcholine: Huperzine-A will increase acetylcholine ranges in rat brains for as much as 6 hours post-administration. Huperzine-A leads to a extra extended enhance in acetylcholine in the entire mind than tacrine, physostigmine, and metrifonate.

Will increase norepinephrine and dopamine: Huperzine-A will increase ranges of norepinephrine and dopamine.

Listed here are just a few of the well being advantages of Huperzine-A:

• – Protects towards poisonous organophosphates
• – Protects neurons towards glutamate toxicity
• – Protects the mind from oxidative injury
• – Helps with recovering from traumatic mind damage and spinal wire damage
• – Might forestall and deal with Alzheimer’s illness

Fig: Huperzine-A suppressed the manufacturing of Reactive Oxygen Species on HT22 cells underneath glutamate stimulation. Cells have been handled with 10 μM of HupA for twenty-four h, adopted by remedy of 5 mM glutamate for 12 h. Outcomes have been offered as imply ± SD (n = 8). ** p < 0.01 versus management group; ## p < 0.01 versus glutamate-treated group.

(Pharmacol Biochem Behav. 2003 Jun;75(3):675-86.)

Saffron Extract (Crocus sativus) (flower)

Saffron is a spice derived from the flower Crocus sativus and has historically been used to taste meals. Saffron incorporates a number of plant compounds that act as highly effective antioxidants and defend cells towards free radicals and oxidative stress that may result in most cancers. These compounds are thought to have antidepressant results, defend mind cells towards injury, lower irritation, and cut back urge for food.

Proof factors to its skill to assist enhance temper, reminiscence, and defend the mind towards oxidative stress.  There are some research that point out that the antioxidants in saffron tea can assist cut back the danger of cardiovascular ailments. Researchers additionally notice that the flavonoids present in saffron can also present safety.

(Rezaee R, Hosseinzadeh H. Safranal: Iran J Primary Med Sci. 2013;16(1):12-26)

REACTION TIME

In a double-blind, placebo-controlled research, key components in FOCUSED-AF have been proven to lower response time and enhance stimulus detection (i.e. greater share right)

MEMORY

Throughout a double-blind, placebo-controlled, randomized research, there was a optimistic correlation between working reminiscence capability (on the x-axis: listening span) and affect of key ingredient in FOCUSED-AF (on the y-axis) 

Throughout a double-blind, placebo-controlled, randomized research, an ingredient (sulbutiamine=S) in FOCUSED-AF at doses of 12.5 mg/kg (S 12.5) and 25 mg/kg (S 25) significantly elevated reminiscence efficiency (imply; S.E.)

FOCUSED-AF is the last word cognitive enhancement complement, backed by scientific analysis and formulated with solely the best high quality components. Its distinctive mixture of nootropics has been proven to reinforce reminiscence, consideration, and focus, cut back psychological errors, and act as an total neuroprotective agent.

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