March 26, 2025
1 min learn
Key takeaways:
- NSAIDs might cut back manipulation underneath anesthesia after TKA.
- For sufferers who can’t take anti-inflammatory medication, corticosteroids could also be an efficient various.
SAN DIEGO — The use of NSAIDs could also be an efficient approach to cut back postoperative stiffness and manipulation underneath anesthesia procedures following complete knee arthroplasty, in response to outcomes offered right here.
“Pharmacologic prophylaxis with anti-inflammatories appears to be an efficient approach to cut back the danger of stiffness and is a crucial a part of our postoperative protocols,” Peter Ok. Sculco, MD, hip and knee surgeon at Hospital for Particular Surgical procedure, advised Healio about outcomes offered on the American Academy of Orthopaedic Surgeons Annual Assembly.
Information had been derived from Selkridge I, et al. Paper 151. Introduced at: American Academy of Orthopaedic Surgeons Annual Assembly; March 10-14, 2025; San Diego.
Sculco and colleagues retrospectively analyzed information from 23,091 sufferers (imply age, 65.4 years; 61% girls) who underwent major TKA from 2017 to 2021 for NSAID prescriptions inside 90 days of surgical procedure, manipulation underneath anesthesia procedures and affected person demographics. The first end result measured was manipulation underneath anesthesia inside 90 days of TKA.
Peter Ok. Sculco
By way of findings, Sculco stated sufferers who had postoperative NSAID prescriptions had a considerably decreased threat for manipulation underneath anesthesia (4.5%) vs. sufferers who had been unable to take NSAIDs for varied causes (12.6%).
Sculco stated additional analysis on options for sufferers who’re unable to take NSAIDs is critical to fight the elevated threat for growing postoperative stiffness requiring manipulation underneath anesthesia.
“For sufferers who can’t take anti-inflammatories, we’ve got to consider options — probably using corticosteroids in these sufferers who’ve allergic reactions or kidney points,” Sculco stated. “Corticosteroids are secure to take after surgical procedure and that has been demonstrated, however additional work is required to see the influence of corticosteroids and whether or not it will probably cut back the danger of manipulation to the extent of the sufferers who had been capable of take anti-inflammatories.”
Sources/Disclosures
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Selkridge I, et al. Paper 151. Introduced at: American Academy of Orthopaedic Surgeons Annual Assembly; March 10-14, 2025; San Diego.
Disclosures:
Sculco reviews no related monetary disclosures.
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