Breakthrough male contraceptive gel exhibits fast ends in scientific trial


A brand new male contraceptive gel, combining two hormones, has demonstrated sooner suppression of sperm manufacturing in comparison with earlier experimental strategies, in accordance with current examine findings. The outcomes of this ongoing multicenter section 2b scientific trial can be introduced on the Endocrine Society’s annual assembly, ENDO 2024, in Boston.

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Revolutionizing male contraception

Senior researcher Diana Blithe, Ph.D., who leads the Contraceptive Growth Program on the Nationwide Institutes of Well being (NIH), emphasised the significance of this improvement. “The event of a secure, extremely efficient, and reliably reversible contraceptive technique for males is an unmet want,” she acknowledged. Blithe identified that whereas some hormonal brokers have proven potential, their gradual onset in suppressing sperm manufacturing has been a major downside.

Research particulars and findings

Funded by the NIH’s Eunice Kennedy Shriver Nationwide Institute of Little one Well being and Human Growth, the examine concerned 222 males who accomplished not less than three weeks of day by day therapy with the contraceptive gel. The gel consists of 8 milligrams (mg) of segesterone acetate, an ingredient additionally used within the Annovera vaginal contraception ring, and 74 mg of testosterone. Individuals utilized the gel as soon as day by day to every shoulder blade.

Researchers measured sperm manufacturing at four-week intervals, defining efficient contraception as a sperm depend of 1 million or fewer per milliliter of semen. By week 15, 86% of individuals achieved this degree of suppression, with a median suppression time of lower than eight weeks. It is a vital enchancment over prior strategies, the place hormonal contraceptives given by injection took between 9 and 15 weeks to realize comparable outcomes.

“A extra fast time to suppression might improve the attractiveness and acceptability of this drug to potential customers,” Blithe famous. The addition of segesterone acetate to testosterone not solely accelerated sperm suppression but in addition allowed for a decrease dose of testosterone, sustaining regular sexual operate and different androgen-dependent actions.

Broader implications

The fast suppression of sperm manufacturing is a key benefit of this new gel, doubtlessly growing its attraction to customers. The continuing section 2b trial will proceed to evaluate the gel’s effectiveness, security, acceptability, and the reversibility of contraception after therapy stops.

Testosterone therapy alone decreases sperm manufacturing, with a median time of 15 weeks. Nonetheless, the mix of segesterone acetate quickens the suppression time and reduces the mandatory dose of testosterone. Within the day by day segesterone-testosterone gel routine, blood ranges of testosterone are saved within the physiologic vary, making certain the upkeep of regular sexual operate and different androgen-dependent actions.

Future outlook

Because the trial progresses, additional insights will emerge concerning the long-term viability and market potential of this contraceptive gel. Its success might pave the best way for future improvements in male contraception, addressing a major hole in reproductive well being choices for males.

For extra detailed findings, regulate updates from the Endocrine Society’s annual assembly and subsequent publications.


This revolutionary gel represents a major step ahead in male contraceptive strategies, promising sooner and more practical suppression of sperm manufacturing. With continued analysis and improvement, it holds the potential to turn into a extensively accepted possibility, providing males better management over their reproductive well being.


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