Endoscopic gastric transforming surgical procedure efficient in managing weight problems

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Key takeaways:

  • Sufferers who underwent the Major Weight problems Surgical procedure Endoluminal 2.0 process reached 14% whole physique weight reduction at 12 months.
  • No critical antagonistic occasions associated to the system or process had been reported.

WASHINGTON — The Major Weight problems Surgical procedure Endoluminal 2.0 process is aprotected, efficient and sturdy choice” for weight reduction and enchancment in obesity-related situations, based on a presenter.

“Present remedy choices for weight problems have limitations in efficacy, value, sturdiness and invasiveness,” Barham Ok. Abu Dayyeh, MD, MPH, director of superior endoscopy and professor of medication at Mayo Clinic, instructed Healio. “The POSE2.0 process represents a novel strategy designed to beat a few of these challenges by creating sturdy, full-thickness plications within the abdomen by way of an incisionless strategy, with out eradicating any components of the abdomen.”



“POSE2.0 represents a significant advancement in endoscopic bariatric therapies. It offers a safe, effective and durable option for patients seeking weight loss and improvement in obesity-related condition.”- Barham K. Abu Dayyeh, MD, MPH



In a research introduced at Digestive Illness Week, Abu Dayyeh and colleagues randomly assigned 35 sufferers with weight problems from 4 educational facilities to the Major Weight problems Surgical procedure Endoluminal 2.0 (POSE2.0) process with moderate-intensity way of life modifications (imply age, 43.6 years; 12% males) or to way of life modifications alone (imply age, 43.2 years; 10% males). Members had been randomized in an open-label, 5:2 style.

The first outcomes had been share of whole physique weight reduction at 12 months and incidence of antagonistic occasions, with secondary outcomes together with sturdiness of the plications at 12 months and impact on gastric emptying utilizing the 13C-Spirulina Gastric Emptying Breath Take a look at (Cairn Diagnostics).

Based on intention-to-treat evaluation, sufferers within the POSE2.0 group skilled important whole physique weight reduction at 12 months (12.8% ± 7.55%) in contrast with the life-style modifications group (2.5% ± 11.34%; P = .006).

Within the per-protocol evaluation, the POSE2.0 group reached 14% ± 7.64% whole physique weight reduction at 12 months — “with a majority attaining clinically significant weight reduction,” Abu Dayyeh stated.

Additional, no critical antagonistic occasions associated to the system or process had been reported.

“Notably, the results seem sturdy, with plications remaining totally intact on the 12-month endoscopic analysis,” he added.

At 2 and 6 months, there was a “gentle delay” in gastric emptying of 19.5 minutes ± 42.85 minutes and 19.6 minutes ± 31.68 minutes, respectively; nevertheless, this was not related to weight reduction. Moreover, researchers reported no improve in nausea, retching, vomiting or bloating at 1, 2, 6 and 12 months, though there have been constant enhancements in fullness at these time factors.

“POSE2.0 represents a big development in endoscopic bariatric therapies,” Abu Dayyeh instructed Healio. “It presents a protected, efficient and sturdy choice for sufferers looking for weight reduction and enchancment in obesity-related situations.”

He added, “Whereas these preliminary outcomes are promising, a bigger comparative trial is underway to additional validate the efficacy and security of POSE2.0 in comparison with different established bariatric interventions. We’re additionally dedicated to investigating its long-term affect on weight reduction and cost-effectiveness in comparison with different medical and surgical choices, and total well being outcomes in numerous affected person populations.”

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